Abstract
1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani. In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein. Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antifungal Agents / pharmacology
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Fungal Proteins / antagonists & inhibitors
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Fungal Proteins / chemistry*
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Fungal Proteins / metabolism
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Ligands
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Molecular Docking Simulation*
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Molecular Sequence Data
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Phenazines / chemistry
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Phenazines / pharmacology
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Protein Structure, Secondary
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Rhizoctonia / drug effects
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Rhizoctonia / metabolism*
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Ribosomal Protein S9
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Ribosomal Proteins / antagonists & inhibitors
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Ribosomal Proteins / chemistry*
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Ribosomal Proteins / metabolism
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Ribosome Subunits, Small, Eukaryotic / chemistry*
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Ribosome Subunits, Small, Eukaryotic / metabolism
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Structural Homology, Protein*
Substances
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Antifungal Agents
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Fungal Proteins
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Ligands
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Phenazines
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Ribosomal Protein S9
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Ribosomal Proteins
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1-hydroxyphenazine