Organocatalytic enantioselective and (Z)-selective allylation of 3-indolylmethanol via hydrogen-bond activation

Chem Commun (Camb). 2014 Oct 18;50(81):12054-7. doi: 10.1039/c4cc02056a.

Abstract

An organocatalytic asymmetric allylation of 3-indolylmethanol has been established via hydrogen-bond activating mode, which directly assembles isatin-derived 3-indolylmethanols and o-hydroxystyrenes into chiral allyl-substituted oxindoles with one all-carbon quaternary stereogenic center and one newly formed C=C bond in excellent enantioselectivity and (Z)-selectivity (up to 97% ee, >20 : 1 Z/E ratio). This transformation provides an efficient strategy for asymmetric C3-functionalization of indoles and allylation of 3-indolylmethanols with precise control of the stereoselectivity in the formation of C-C and C=C bonds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Catalysis
  • Hydrogen / chemistry
  • Hydrogen Bonding
  • Indoles / chemical synthesis
  • Indoles / chemistry*
  • Isatin / chemistry
  • Oxindoles
  • Stereoisomerism
  • Styrenes / chemistry

Substances

  • Aldehydes
  • Indoles
  • Oxindoles
  • Styrenes
  • 2-oxindole
  • Hydrogen
  • Isatin