Orbital Involvement by NUT Midline Carcinoma

Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec;31(6):e147-50. doi: 10.1097/IOP.0000000000000179.

Abstract

A 32-year-old female presented with a sino-orbital lesion that proved to be a NUT midline carcinoma. This is only the third case of orbital involvement by this aggressive lesion. The clinical, radiographic, and histopathologic features of NUT midline carcinoma are discussed, as well as its management options.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / therapy
  • Cell Cycle Proteins
  • Chemoradiotherapy
  • Chromosomes, Human, Pair 15 / genetics
  • Chromosomes, Human, Pair 19 / genetics
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Magnetic Resonance Imaging
  • Neoplasm Proteins / metabolism
  • Nuclear Proteins / genetics*
  • Oncogene Proteins / genetics*
  • Orbital Neoplasms / diagnosis*
  • Orbital Neoplasms / genetics
  • Orbital Neoplasms / therapy
  • Positron-Emission Tomography
  • Pregnancy
  • Tomography, X-Ray Computed
  • Transcription Factors / genetics
  • Translocation, Genetic / genetics

Substances

  • BRD4 protein, human
  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • NUTM1 protein, human
  • Neoplasm Proteins
  • Nuclear Proteins
  • Oncogene Proteins
  • Transcription Factors