We have comparatively studied the adherence of Staphylococcus epidermidis and S. saprophyticus to epithelial cells of a continuous cellular line of urinary origin (MDCK). The adherence of S. saprophyticus was significantly higher than that of S. epidermidis and this phenomenon was not related to the bacterial surface hydrophobicity or the ability of producing slime in vitro. The pre-incubation of the bacteria with sub-inhibitory concentrations of vancomycin, teicoplanin, amikacin, clindamycin, and roxitromycin did not modify the adherence ability of the microorganisms. Of the antimicrobial agents evaluated, only clindamycin significantly agents evaluated, only clindamycin, significantly inhibited the ability of producing slime of S. saprophyticus strains.