Microfluidic techniques for development of 3D vascularized tissue

Anwarul Hasan; Arghya Paul; Nihal E Vrana; Xin Zhao; Adnan Memic; Yu-Shik Hwang; Mehmet R Dokmeci; Ali Khademhosseini

doi:10.1016/j.biomaterials.2014.04.091

Microfluidic techniques for development of 3D vascularized tissue

Biomaterials. 2014 Aug;35(26):7308-25. doi: 10.1016/j.biomaterials.2014.04.091. Epub 2014 Jun 3.

Authors

Anwarul Hasan¹, Arghya Paul², Nihal E Vrana³, Xin Zhao⁴, Adnan Memic⁵, Yu-Shik Hwang⁶, Mehmet R Dokmeci⁴, Ali Khademhosseini⁷

Affiliations

¹ Biomedical Engineering, and Department of Mechanical Engineering, American University of Beirut, Beirut 1107 2020, Lebanon; Biomaterials Innovation Research Center, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: mh211@aub.edu.lb.
² Biomaterials Innovation Research Center, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
³ INSERM, UMR-S 1121, Biomatériaux et Bioingénierie, 11 rue Humann, F-67085 Strasbourg Cedex, France.
⁴ Biomaterials Innovation Research Center, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
⁵ Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
⁶ Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea.
⁷ Biomaterials Innovation Research Center, Division of Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; World Premier International - Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Sendai 980-8577, Japan; Department of Physics, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: alik@rics.bwh.harvard.edu.

Abstract

Development of a vascularized tissue is one of the key challenges for the successful clinical application of tissue engineered constructs. Despite the significant efforts over the last few decades, establishing a gold standard to develop three dimensional (3D) vascularized tissues has still remained far from reality. Recent advances in the application of microfluidic platforms to the field of tissue engineering have greatly accelerated the progress toward the development of viable vascularized tissue constructs. Numerous techniques have emerged to induce the formation of vascular structure within tissues which can be broadly classified into two distinct categories, namely (1) prevascularization-based techniques and (2) vasculogenesis and angiogenesis-based techniques. This review presents an overview of the recent advancements in the vascularization techniques using both approaches for generating 3D vascular structure on microfluidic platforms.

Keywords: Angiogenesis; Microfluidics; Micromolding; Tissue engineering; Vascularization; Vasculogenesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Blood Vessels / cytology
Blood Vessels / physiology*
Equipment Design
Humans
Microfluidic Analytical Techniques / instrumentation*
Microfluidic Analytical Techniques / methods
Microfluidics / instrumentation
Microfluidics / methods*
Neovascularization, Physiologic*
Tissue Engineering / instrumentation*
Tissue Engineering / methods

Abstract

Publication types

MeSH terms

Grants and funding