Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concentration"

Am J Physiol Cell Physiol. 2014 Oct 1;307(7):C595-6. doi: 10.1152/ajpcell.00184.2014. Epub 2014 Jun 18.
No abstract available

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Aquaporin 2 / drug effects*
  • Cell Membrane / drug effects*
  • High-Throughput Screening Assays*
  • Kidney / drug effects*
  • Kidney Concentrating Ability / drug effects*
  • Tyrphostins / pharmacology*
  • Urological Agents / pharmacology*

Substances

  • Aqp2 protein, rat
  • Aquaporin 2
  • Tyrphostins
  • Urological Agents
  • alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide