Radiation enhancement of lung nodule formation in mice is not potentiated by treatment with a perfluorochemical emulsion and carbogen

Radiother Oncol. 1989 Jan;14(1):49-53. doi: 10.1016/0167-8140(89)90008-x.

Abstract

The ability of intravenously-injected mouse mammary tumor cells to form lung tumors is increased by irradiation of the thorax 24 h previously. We examined the effects of treatment with a perfluorochemical emulsion (Fluosol-DA, 20%) plus carbogen before and during irradiation on the radiation-induced enhancement of lung nodule formation. We found no evidence that treatment with Fluosol plus carbogen altered the development of tumor nodules in irradiated mouse lungs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carbon Dioxide / toxicity*
  • Drug Combinations / toxicity
  • Female
  • Fluorocarbons / toxicity*
  • Hydroxyethyl Starch Derivatives
  • Lung Neoplasms / etiology*
  • Mice
  • Mice, Inbred BALB C
  • Neoplasm Transplantation
  • Neoplasms, Radiation-Induced*
  • Radiation Dosage

Substances

  • Drug Combinations
  • Fluorocarbons
  • Hydroxyethyl Starch Derivatives
  • Carbon Dioxide
  • glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination