[Impact of anti-HLA antibodies on outcomes of allogeneic stem cell transplantation: a report by the SFGM-TC]

P Loiseau; V Dubois; B Bonafoux; C-E Bulabois; V Coiteux; J-F Eliaou; M Labaky; M Michallet; V Renac; F Delbos; A Kennel; M Detrait; A Devys; C Galambrun; I Yakoub-Agha; SFGM-TC

doi:10.1016/j.patbio.2014.05.007

[Impact of anti-HLA antibodies on outcomes of allogeneic stem cell transplantation: a report by the SFGM-TC]

Pathol Biol (Paris). 2014 Aug;62(4):226-9. doi: 10.1016/j.patbio.2014.05.007. Epub 2014 Jun 25.

[Article in French]

Authors

P Loiseau¹, V Dubois², B Bonafoux³, C-E Bulabois⁴, V Coiteux⁵, J-F Eliaou⁶, M Labaky⁷, M Michallet⁸, V Renac⁹, F Delbos⁷, A Kennel¹⁰, M Detrait⁸, A Devys¹¹, C Galambrun¹², I Yakoub-Agha¹³; SFGM-TC

Affiliations

¹ Centre receveur/greffe de moelle, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.
² Laboratoire HLA, EFS Rhône-Alpes, 1 et 3, rue du Vercors, 69007 Lyon, France.
³ Laboratoire d'immunologie, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.
⁴ Service d'hématologie, hôpital Albert-Michallon, BP 210, 38043 Grenoble cedex 09, France.
⁵ Maladies du sang, CHRU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France.
⁶ Laboratoire d'immunologie, hôpital Saint-Éloi, 2, avenue Bertin-Sans, 34295 Montpellier cedex 5, France.
⁷ Laboratoire HLA-ILP, EFS Île-de-France, 1, voie Félix-Eboué, 94000 Créteil, France.
⁸ Service d'hématologie secteur 1G, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite, France.
⁹ Histocompatibilité et immunogénétique, EFS Bretagne, site de Rennes, rue Pierre-Jean-Gineste, 35016 Rennes cedex, France.
¹⁰ Laboratoire d'histocompatibilité, CHU de Nancy, rue du Morvan, 54500 Vandœuvre-Lès-Nancy, France.
¹¹ Laboratoire HLA-EFS, pays de la Loire, 34, rue Jean-Monnet, BP 91115, 44011 Nantes cedex 1, France.
¹² Service d'hématologie pédiatrique, hôpital d'enfants de la Timone, boulevard Jean-Moulin, 13385 Marseille cedex 05, France.
¹³ Maladies du sang, CHRU de Lille, rue Michel-Polonovski, 59037 Lille cedex, France. Electronic address: sfgm-tc-iya@live.fr.

PMID: 24973858
DOI: 10.1016/j.patbio.2014.05.007

Abstract

The role of anti-HLA antibodies in allogeneic stem cell transplantation setting is still unclear. In the attempt to harmonize clinical practices between different French transplantation centers, the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC) set up its fourth annual series of workshops which brought together practitioners from all of its member centers. These workshops took place in September 2013 in Lille. This article offers the recommendations of the group that considered the impact that have anti-HLA antibodies on outcomes in allogeneic stem cell transplantation.

Keywords: Allogeneic stem cell transplantation; Allogreffe de cellules souches hématopoïétiques; Anti-HLA antibodies; Anticorps anti-HLA; Anticorps spécifique anti-HLA du donneur; Donor-specific antibody.

Publication types

English Abstract
Practice Guideline
Research Support, Non-U.S. Gov't

MeSH terms

France
HLA Antigens / immunology*
Histocompatibility Testing
Humans
Isoantibodies / adverse effects*
Isoantibodies / analysis
Stem Cell Transplantation*
Tissue Donors
Transplantation, Homologous*
Treatment Outcome*

Substances

HLA Antigens
Isoantibodies