Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development

Jan van der Greef; Aram Adourian; Pieter Muntendam; Robert N McBurney

doi:10.1016/j.ddtec.2006.05.003

Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development

Drug Discov Today Technol. 2006 Summer;3(2):205-11. doi: 10.1016/j.ddtec.2006.05.003.

Authors

Jan van der Greef¹, Aram Adourian², Pieter Muntendam³, Robert N McBurney²

Affiliations

¹ TNO Systems Biology, Netherlands Organization for Applied Scientific Research, Zeist, Netherlands.
² BG Medicine, Inc., Waltham, MA 02451, USA.
³ BG Medicine, Inc., Waltham, MA 02451, USA. Electronic address:PMuntendam@bg-medicine.com.

PMID: 24980409
DOI: 10.1016/j.ddtec.2006.05.003

Abstract

Too few drug discovery projects generate a marketed drug product, often because preclinical studies fail to predict the clinical experience with a drug candidate. Improving the success of preclinical-to-clinical translation is of paramount importance in optimizing the pharmaceutical value chain. Here, we advance the case for a molecular systems approach to crossing the preclinical-to-clinical translational chasm and for metabolomic analysis of readily accessible bodyfluids as a key technology in translational activities.:

� 2006 Published by Elsevier Ltd.