Smart polymeric micelles for gene and drug delivery

Nobuhiro Nishiyama; Younsoo Bae; Kanjiro Miyata; Shigeto Fukushima; Kazunori Kataoka

doi:10.1016/j.ddtec.2005.05.007

Smart polymeric micelles for gene and drug delivery

Drug Discov Today Technol. 2005 Spring;2(1):21-6. doi: 10.1016/j.ddtec.2005.05.007.

Authors

Nobuhiro Nishiyama¹, Younsoo Bae², Kanjiro Miyata², Shigeto Fukushima², Kazunori Kataoka³

Affiliations

¹ Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
² Department of Materials Science and Engineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
³ CREST, Japan Science and Technology Agency, Japan. Electronic address:kataoka@bmw.t.u-tokyo.ac.jp.

PMID: 24981751
DOI: 10.1016/j.ddtec.2005.05.007

Abstract

Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with smart functions, such as targetability and stimuli-sensitivity, have emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This review focuses on the construction and characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.: