Brønsted acid catalyzed benzylic C-H bond functionalization of azaarenes: nucleophilic addition to nitroso compounds

Org Lett. 2014 Jul 18;16(14):3664-7. doi: 10.1021/ol501422k. Epub 2014 Jul 1.

Abstract

A practical Brønsted acid promoted benzylic C-H functionalization of 2-alkylazaarenes and nucleophilic addition to nitroso compounds was developed under mild conditions. Switched by Brønsted acids, this method can afford azaarene-2-aldimines, azaarene-2-carbaldehyde, or azaarene-2-oximes selectively. No metal, base, oxidant, or other additives were required.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aza Compounds / chemical synthesis*
  • Aza Compounds / chemistry*
  • Catalysis
  • Molecular Structure
  • Nitroso Compounds / chemistry*

Substances

  • Aza Compounds
  • Nitroso Compounds