Toxic myopathies

Neurol Clin. 2014 Aug;32(3):647-70, viii. doi: 10.1016/j.ncl.2014.04.009.

Abstract

Muscle tissue is highly sensitive to many substances. Early recognition of toxic myopathies is important, because they potentially are reversible on removal of the offending drug or toxin, with greater likelihood of complete resolution the sooner this is achieved. Clinical features range from mild muscle pain and cramps to severe weakness with rhabdomyolysis, renal failure, and even death. The pathogenic bases can be multifactorial. This article reviews some of the common toxic myopathies and their clinical presentation, histopathologic features, and possible underlying cellular mechanisms.

Keywords: Muscle tissue; Myopathy; Statins; Toxic myopathies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Anticholesteremic Agents / adverse effects*
  • Creatine Kinase / blood
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Male
  • Muscular Diseases / chemically induced*
  • Muscular Diseases / diagnosis
  • Propofol / adverse effects
  • Toxins, Biological / adverse effects

Substances

  • Anticholesteremic Agents
  • Immunosuppressive Agents
  • Toxins, Biological
  • Creatine Kinase
  • Propofol