Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding

Affiliations

• ¹ Department of Microbiology and Immunology, Experimental Laboratory Immunology, Katholieke Universiteit Leuven, Leuven, Belgium.
• ² Department of Microbiology and Immunology, Experimental Laboratory Immunology, Katholieke Universiteit Leuven, Leuven, Belgium; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
• ³ Laboratory Genetics of Autoimmunity, Vlaams Instituut Biotechnologie, Leuven, Belgium; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
• ⁴ Department of Microbiology and Immunology, Laboratory for Clinical Bacteriology and Mycology, Katholieke Universiteit Leuven, Leuven, Belgium.
• ⁵ Laboratory Genetics of Autoimmunity, Vlaams Instituut Biotechnologie, Leuven, Belgium.
• ⁶ Centre for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany.
• ⁷ Primary Immunodeficiency Group, Institute of Cellular Medicine, Newcastle University and Pediatric Immunology Service, Great North Children's Hospital, Newcastle upon Tyne, United Kingdom.
• ⁸ Department of Conservative Dentistry, School for Dentistry, Katholieke Universiteit Leuven, University Hospitals Leuven, Leuven, Belgium.
• ⁹ Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium.
• ¹⁰ Department of Cellular and Molecular Medicine, Laboratory of Molecular Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.
• ¹¹ Department of Microbiology and Immunology, Experimental Laboratory Immunology, Katholieke Universiteit Leuven, Leuven, Belgium; Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium. Electronic address: Isabelle.Meyts@uzleuven.be.