A schematic workflow for collecting information about the interaction between copy number variants and microRNAs using existing resources

Methods Mol Biol. 2014:1182:307-20. doi: 10.1007/978-1-4939-1062-5_26.

Abstract

MicroRNAs (miRNAs) and copy number variations (CNVs) are two extensively studied genomic components in the field of modern biology-as they have been found to be associated with many disorders such as cancer, Alzheimer, pancreatitis, HIV susceptibility, beta-thalassemia, and glomerulonephritis. Several studies suggested that an alteration in CNV-miRNA interaction could result in some human diseases such as cancer. Therefore, the possible miRNA-binding site information within the CNV genes opens new avenues in understanding such disorders. In this chapter, we present a schematic approach for collecting the information on CNV-miRNA interactions using miRWalk and TargetScan databases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computational Biology / methods*
  • DNA Copy Number Variations / genetics*
  • Databases, Genetic
  • Humans
  • MicroRNAs / genetics*
  • Workflow

Substances

  • MicroRNAs