Abstract
Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-related dysfunction that could be targeted by novel therapies were found using novel, state-of-the-art techniques to address this issue.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Carbon Isotopes
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Citric Acid Cycle
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Depressive Disorder, Major / metabolism*
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Female
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Glutamic Acid / metabolism*
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Humans
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Magnetic Resonance Spectroscopy* / methods
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Male
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Middle Aged
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Mitochondria / metabolism*
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Models, Biological
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Neuroimaging / methods*
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Occipital Lobe / metabolism*
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Protons
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Young Adult
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gamma-Aminobutyric Acid / metabolism
Substances
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Carbon Isotopes
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Protons
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Glutamic Acid
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gamma-Aminobutyric Acid