Glutamate metabolism in major depressive disorder

Am J Psychiatry. 2014 Dec 1;171(12):1320-7. doi: 10.1176/appi.ajp.2014.14010067. Epub 2014 Oct 31.

Abstract

Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function. Signs of a specific form of glutamate-related dysfunction that could be targeted by novel therapies were found using novel, state-of-the-art techniques to address this issue.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carbon Isotopes
  • Citric Acid Cycle
  • Depressive Disorder, Major / metabolism*
  • Female
  • Glutamic Acid / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy* / methods
  • Male
  • Middle Aged
  • Mitochondria / metabolism*
  • Models, Biological
  • Neuroimaging / methods*
  • Occipital Lobe / metabolism*
  • Protons
  • Young Adult
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Carbon Isotopes
  • Protons
  • Glutamic Acid
  • gamma-Aminobutyric Acid