Alkynes as allylmetal equivalents in redox-triggered C-C couplings to primary alcohols: (Z)-homoallylic alcohols via ruthenium-catalyzed propargyl C-H oxidative addition

J Am Chem Soc. 2014 Aug 27;136(34):11902-5. doi: 10.1021/ja505962w. Epub 2014 Jul 30.

Abstract

The cationic ruthenium catalyst generated upon the acid-base reaction of H2Ru(CO)(PPh3)3 and 2,4,6-(2-Pr)3PhSO3H promotes the redox-triggered C-C coupling of 2-alkynes and primary alcohols to form (Z)-homoallylic alcohols with good to complete control of olefin geometry. Deuterium labeling studies, which reveal roughly equal isotopic compositions at the allylic and distal vinylic positions, along with other data, corroborate a catalytic mechanism involving ruthenium(0)-mediated allene-aldehyde oxidative coupling to form a transient oxaruthenacycle, an event that ultimately defines (Z)-olefin stereochemistry.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry
  • Alkynes / chemistry*
  • Allyl Compounds / chemistry*
  • Catalysis
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Oxidation-Reduction
  • Propanols / chemistry*
  • Ruthenium / chemistry*
  • Stereoisomerism

Substances

  • Alcohols
  • Alkynes
  • Allyl Compounds
  • Organometallic Compounds
  • Propanols
  • Ruthenium
  • propargyl alcohol