Mouse models address key concerns regarding autophagy inhibition in cancer therapy

Cancer Discov. 2014 Aug;4(8):873-5. doi: 10.1158/2159-8290.CD-14-0618.

Abstract

With multiple clinical trials under way targeting autophagy against cancer, Yang and colleagues and Karsli-Uzunbas and colleagues address important concerns regarding autophagy inhibition in patients with cancer, using genetically engineered mouse models that more accurately represent the tumor biology found in human patients with pancreatic and lung cancers.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy / genetics*
  • Carcinoma, Non-Small-Cell Lung / genetics*
  • Cell Transformation, Neoplastic / genetics*
  • Glucose / metabolism*
  • Humans
  • Lung Neoplasms / genetics*
  • Pancreatic Neoplasms / genetics*
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Glucose