Imaging of rats with mammary cancer with two 2-deoxy-2-[18F]fluoro-D-hexoses

Int J Rad Appl Instrum B. 1989;16(5):449-53. doi: 10.1016/0883-2897(89)90054-8.

Abstract

Rats with mammary cancer were imaged by scintigraphy: 10 rats with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and 10 rats with [18F]F-D-galactose. The uptake of both tracers was similar in the tumors--the tumor-to-normal tissue ratio was 2.7 +/- 1.1 for [18F]FDG and 2.3 +/- 0.9 for [18F]FDGal at 120 min after injection. In addition to the tumors [18F]FDG accumulated in the brain, bladder and heart, [18F]FDGal in the brain, bladder and liver. [18F]FDGal may be useful for tumor imaging in man; further studies should be addressed to elucidate the mechanism of [18F]FDGal uptake into tumors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Deoxyglucose / pharmacokinetics
  • Female
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18
  • Fucose / analogs & derivatives
  • Fucose / pharmacokinetics
  • Galactose
  • Mammary Neoplasms, Experimental / chemically induced
  • Mammary Neoplasms, Experimental / diagnostic imaging*
  • Radionuclide Imaging
  • Rats
  • Rats, Inbred Strains

Substances

  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • Fucose
  • 9,10-Dimethyl-1,2-benzanthracene
  • Deoxyglucose
  • 2-deoxy-2-fluorogalactose
  • Galactose