Abstract
Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Blood Coagulation Factors / physiology*
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Fibrosis
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Heart Valve Diseases / physiopathology
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Hemostasis
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Humans
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Hypertension / physiopathology
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Hypertension, Pulmonary / physiopathology
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Hypertrophy
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Models, Cardiovascular
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Myocardial Infarction / physiopathology
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Myocarditis / physiopathology
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Myocarditis / virology
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Myocytes, Cardiac / pathology
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Receptors, Proteinase-Activated / physiology*
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Renin-Angiotensin System / physiology
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Thromboplastin / physiology*
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Ventricular Remodeling / physiology*
Substances
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Blood Coagulation Factors
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Receptors, Proteinase-Activated
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Thromboplastin