Dapsone-induced haemolytic anaemia and agranulocytosis in a patient with normal glucose-6-phosphate-dehydrogenase activity

Acta Haematol. 1989;82(3):144-5. doi: 10.1159/000205363.

Abstract

A case of dapsone-induced severe haemolytic anaemia and agranulocytosis is described. A possible common pathogenic mechanism for the simultaneous occurrence of these side effects of dapsone therapy in a patient with normal glucose-6-phosphate-dehydrogenase activity is proposed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Agranulocytosis / chemically induced*
  • Anemia, Hemolytic / chemically induced*
  • Dapsone / adverse effects*
  • Dapsone / metabolism
  • Female
  • Glucosephosphate Dehydrogenase / analysis*
  • Humans

Substances

  • Dapsone
  • Glucosephosphate Dehydrogenase