The mycobacterial cell envelope-lipids

Cold Spring Harb Perspect Med. 2014 Aug 7;4(10):a021105. doi: 10.1101/cshperspect.a021105.

Abstract

Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key aspect of tuberculosis (TB) basic and translational research. Although the interest in these compounds originally stemmed from their abundance, structural diversity, and antigenicity, continued research in this field has been driven by their important contribution to TB pathogenesis and their interest from the perspective of drug, vaccine, diagnostic, and biomarker development. This article summarizes what is known of the roles of lipids in the physiology and pathogenicity of Mtb and the exciting developments that have occurred in recent years in identifying new lead compounds targeting their biogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Membrane / ultrastructure
  • Drug Design*
  • Lipopolysaccharides / chemistry
  • Lipopolysaccharides / metabolism*
  • Membrane Lipids / antagonists & inhibitors*
  • Membrane Lipids / chemistry
  • Membrane Lipids / metabolism*
  • Molecular Structure
  • Mycobacterium tuberculosis / metabolism*
  • Mycobacterium tuberculosis / pathogenicity*
  • Mycolic Acids / antagonists & inhibitors
  • Mycolic Acids / metabolism
  • Signal Transduction
  • Terpenes / metabolism

Substances

  • Lipopolysaccharides
  • Membrane Lipids
  • Mycolic Acids
  • Terpenes