What is different about patients with hematologic malignancies? A retrospective cohort study of cancer patients referred to a hospice research network

J Pain Symptom Manage. 2015 Mar;49(3):505-12. doi: 10.1016/j.jpainsymman.2014.07.003. Epub 2014 Aug 10.

Abstract

Context: Although much is known about solid tumor patients who use hospice, the hematologic malignancies hospice population is inadequately described.

Objectives: To compare the characteristics and outcomes of hospice patients with hematologic malignancies to those with solid tumors.

Methods: We extracted electronic patient data (2008-2012) from a large hospice network (Coalition of Hospices Organized to Investigate Comparative Effectiveness) and used bivariate analyses to describe between-group differences.

Results: In total, 48,147 patients with cancer were admitted during the study period; 3518 (7.3%) had a hematologic malignancy. These patients had significantly worse Palliative Performance Scale scores (32% vs. 24% were below 40; P < 0.001) and shorter lengths of stay (median 11 vs. 19 days; P < 0.001). They were more likely to die within 24 hours of hospice enrollment (10.9% vs. 6.8%; odds ratio [OR] 1.66; 95% CI 1.49, 1.86; P < 0.001) or within seven days (36% vs. 25.1%; OR 1.68; 95% CI 1.56, 1.81; P < 0.001) and were more likely to receive hospice services in an inpatient or nursing home setting (OR 1.34; 95% CI 1.16, 1.56 and OR 1.54; 95% CI 1.39, 1.72; both P < 0.001). Among hematologic malignancy patients, those with leukemia had the shortest survival (hazard ratio 1.23; 95% CI 1.13, 1.34; P < 0.001), and 40.3% used hospice for less than seven days (OR 1.31; 95% CI 1.11, 1.56; P = 0.002).

Conclusion: Hospice patients with hematologic malignancies are more seriously ill at the time of admission, with worse functional status and shorter lengths of stay than other cancer patients. Differences in outcomes suggest the need for targeted interventions to optimize hospice services for the hematologic malignancies population, especially those with leukemia.

Keywords: Palliative care; comparative effectiveness research; hematologic neoplasms; hospices.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Hematologic Neoplasms / epidemiology*
  • Hematologic Neoplasms / therapy*
  • Hospice Care / statistics & numerical data
  • Hospices / statistics & numerical data
  • Humans
  • Inpatients / statistics & numerical data
  • Length of Stay
  • Logistic Models
  • Male
  • Middle Aged
  • Nursing Homes / statistics & numerical data
  • Odds Ratio
  • Retrospective Studies
  • Severity of Illness Index