Activated protein C resistance assay and factor V Leiden

N Engl J Med. 2014 Aug 14;371(7):685-6. doi: 10.1056/NEJMc1405664.

Abstract

The authors suggest that functional testing for activated protein C resistance is cheaper and more clinically relevant than genetic testing to detect a factor V Leiden mutation in identifying persons who are at risk for thromboembolism.

Publication types

  • Letter

MeSH terms

  • Activated Protein C Resistance / diagnosis*
  • Activated Protein C Resistance / genetics
  • Factor V / genetics*
  • Female
  • Genotype
  • Humans
  • Partial Thromboplastin Time / economics
  • Phenotype
  • Point Mutation
  • Polymerase Chain Reaction / economics

Substances

  • factor V Leiden
  • Factor V

Supplementary concepts

  • Thrombophilia due to Activated Protein C Resistance