Effects of ecstasy on cooperative behaviour and perception of trustworthiness: a naturalistic study

J Psychopharmacol. 2014 Nov;28(11):1001-8. doi: 10.1177/0269881114544775. Epub 2014 Aug 13.

Abstract

Background: Acute recreational use of 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') can promote pro-social effects which may alter interpersonal perceptions.

Aims: To explore such effects, this study investigated whether acute recreational use of ecstasy was associated with changes in individual perception of trustworthiness of people's faces and co-operative behaviours.

Method: An independent group, repeated measures design was used in which 17 ecstasy users were tested on the night of drug use (day 0) and again three days later (day 3); 22 controls were tested on parallel days. On each day, participants rated the trustworthiness of 66 faces, carried out three co-operative behaviour tasks (public good; dictator; ultimatum game) and completed mood self-ratings.

Results: Acute ecstasy use was associated with increased face trustworthiness ratings and increased cooperative behaviour on the dictator and ultimatum games; on day 3 there were no group differences on any task. Self-ratings showed the standard acute ecstasy effects (euphoria, energy, jaw clenching) with negative effects (less empathy, compassion, more distrust, hostility) emerging on day 3.

Conclusions: Our findings of increased perceived trustworthiness and co-operative behaviours following use of ecstasy suggest that a single dose of the drug enhances aspects of empathy. This may in turn contribute to its popularity as a recreational drug and potentially to its enhancement of the therapeutic alliance in psychotherapy.

Keywords: 3,4-methylenedioxymethamphetamine; Co-operation; acute; ecstasy; pro-social; psychological therapy; sub-acute; trust.

Publication types

  • Observational Study

MeSH terms

  • Affect / drug effects
  • Case-Control Studies
  • Cooperative Behavior*
  • Facial Expression
  • Female
  • Humans
  • Male
  • N-Methyl-3,4-methylenedioxyamphetamine / pharmacology*
  • Social Perception*
  • Trust / psychology*
  • Young Adult

Substances

  • N-Methyl-3,4-methylenedioxyamphetamine