Activating PI3-kinase to dampen inflammation

Chem Biol. 2014 Aug 14;21(8):917-8. doi: 10.1016/j.chembiol.2014.07.012.

Abstract

Diterpene derivatives of the natural product acanthoic acid have potent anti-inflammatory effects in vivo. In this issue of Chemistry & Biolgy, Través and colleagues report that the primary molecular mechanism of action of diterpenes structurally related to acanthoic acid is the direct activation of PI3-kinase signaling in macrophages, which in turn inhibits NF-κB activation and suppresses proinflammatory gene expression.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Class Ia Phosphatidylinositol 3-Kinase / chemistry*
  • Class Ia Phosphatidylinositol 3-Kinase / metabolism*
  • Diterpenes / pharmacology*
  • NF-kappa B / antagonists & inhibitors*
  • Protein Subunits / metabolism*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Diterpenes
  • NF-kappa B
  • Protein Subunits
  • acanthoic acid
  • Class Ia Phosphatidylinositol 3-Kinase