Effective treatment of invasive Aspergillus fumigatus infection using combinations of topical and systemic antifungals in a severely burned patient

J Burn Care Res. 2015 Mar-Apr;36(2):e85-9. doi: 10.1097/BCR.0000000000000143.

Abstract

The authors describe an invasive Aspergillus fumigatus deep-burn wound infection in a severely burned patient that was successfully treated with a combination of topical terbinafine and systemic voriconazole antifungal therapy. To our knowledge, this is the first case report describing the effective control of an invasive deep-burn wound infection using this combination.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Adult
  • Antifungal Agents / administration & dosage*
  • Aspergillosis / drug therapy*
  • Aspergillosis / microbiology
  • Aspergillus fumigatus / isolation & purification
  • Blast Injuries / complications
  • Blast Injuries / drug therapy*
  • Burns / complications
  • Burns / drug therapy*
  • Fatal Outcome
  • Humans
  • Male
  • Sepsis / drug therapy*
  • Sepsis / microbiology
  • Wound Infection / drug therapy*
  • Wound Infection / microbiology

Substances

  • Antifungal Agents