Targeted theranostic prodrugs based on an aggregation-induced emission (AIE) luminogen for real-time dual-drug tracking

Chem Commun (Camb). 2014 Oct 9;50(78):11465-8. doi: 10.1039/c4cc05255b.

Abstract

A targeted theranostic delivery system containing two prodrugs with drug tracking and activation monitoring functions was developed for visualizing cancer cell ablation with synergistic anticancer effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cisplatin / chemistry
  • Cisplatin / toxicity
  • Doxorubicin / chemistry
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry
  • Fluorescent Dyes / chemistry
  • HEK293 Cells
  • Humans
  • Microscopy, Confocal
  • Peptides, Cyclic / chemistry
  • Prodrugs / chemistry*
  • Prodrugs / toxicity

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Fluorescent Dyes
  • Peptides, Cyclic
  • Prodrugs
  • cyclic arginine-glycine-aspartic acid peptide
  • Doxorubicin
  • Cisplatin