Abstract
Importance:
The cause of follicular spicules in multiple myeloma (MM) is not known.
Observations:
We present a case of follicular spicules in a patient with MM, which is very reminiscent of trichodysplasia spinulosa caused by a polyomavirus. No trichodysplasia spinulosa-associated polyomavirus could be isolated from the skin lesions; however, the spicules were positive for Merkel cell carcinoma virus, which is also a polyomavirus.
Conclusions and relevance:
Follicular spicules in MM are probably not caused by the trichodysplasia spinulosa-associated virus. Merkel cell polyomavirus could contribute to the origin of this dermatosis.
Publication types
-
Case Reports
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Antiviral Agents / administration & dosage
-
Antiviral Agents / therapeutic use
-
Carcinoma, Merkel Cell / drug therapy*
-
Carcinoma, Merkel Cell / pathology
-
Carcinoma, Merkel Cell / virology
-
Cidofovir
-
Cytosine / administration & dosage
-
Cytosine / analogs & derivatives*
-
Cytosine / therapeutic use
-
Gels
-
Hair Follicle / pathology
-
Hair Follicle / virology
-
Humans
-
Male
-
Merkel cell polyomavirus / isolation & purification
-
Multiple Myeloma / drug therapy*
-
Multiple Myeloma / pathology
-
Multiple Myeloma / virology
-
Organophosphonates / administration & dosage
-
Organophosphonates / therapeutic use*
-
Polyomavirus Infections / drug therapy
-
Polyomavirus Infections / virology
-
Skin Neoplasms / drug therapy*
-
Skin Neoplasms / pathology
-
Skin Neoplasms / virology
Substances
-
Antiviral Agents
-
Gels
-
Organophosphonates
-
Cytosine
-
Cidofovir