Response to comments on "Local impermeant anions establish the neuronal chloride concentration"

J Glykys; V Dzhala; K Egawa; T Balena; Y Saponjian; K V Kuchibhotla; B J Bacskai; K T Kahle; T Zeuthen; K J Staley

doi:10.1126/science.1253146

Response to comments on "Local impermeant anions establish the neuronal chloride concentration"

Science. 2014 Sep 5;345(6201):1130. doi: 10.1126/science.1253146.

Authors

J Glykys¹, V Dzhala¹, K Egawa¹, T Balena¹, Y Saponjian¹, K V Kuchibhotla², B J Bacskai¹, K T Kahle³, T Zeuthen⁴, K J Staley⁵

Affiliations

¹ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
² New York University School of Medicine, Skirball Institute for Biomolecular Medicine, New York, NY, USA.
³ Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁴ Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.
⁵ Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. staley.kevin@mgh.harvard.edu.

Abstract

We appreciate the interest in our paper and the opportunity to clarify theoretical and technical aspects describing the influence of Donnan equilibria on neuronal chloride ion (Cl(-)) distributions.

Publication types

Comment

MeSH terms

Animals
Brain / metabolism*
Chloride Channels / metabolism*
Chlorides / metabolism*
Neurons / metabolism*
Receptors, GABA-A / metabolism*

Substances

Chloride Channels
Chlorides
Receptors, GABA-A

Abstract

Publication types

MeSH terms

Substances

Grants and funding