Sleep quality in patients with Behçet's disease

Abstract

Aim: The aim of this study was to evaluate sleep quality and the related variables in patients with Behçet's disease (BD).

Method: One hundred and twelve patients diagnosed with BD and 67 age- and gender-matched healthy controls were enrolled in the study. The Pittsburgh Sleep Quality Index (PSQI) was used for the evaluation of sleep disturbance in all participants. The quality of life (QoL) of all patients were evaluated by Nottingham Health Profile (NHP), and anxiety and depression which were assessed by Hospital Anxiety and Depression Scale (HADS).

Results: The patients with BD had significantly higher scores in subjective sleep quality, sleep latency, sleep efficiency, sleep disorder, functional disorder in the morning and total PSQI score compared to the healthy control group. According to Pearson's analysis, there was a significantly higher correlation between the anxiety, depression and all components of NHP scores and the total PSQI score. Logistic regression analyses indicated that genital ulcer and arthritis were predictors for poor sleep quality.

Conclusion: Sleep quality is disturbed in patients with BD. The lower quality of sleep is greatly associated with anxiety, depression, QoL, genital ulcers and arthritis.

Keywords: Behçet's disease; anxiety; depression; quality of life; sleep quality.