Centromere licensing: Mis18 is required to Polo-ver

Meghan C Barnhart-Dailey; Daniel R Foltz

doi:10.1016/j.cub.2014.07.026

Centromere licensing: Mis18 is required to Polo-ver

Curr Biol. 2014 Sep 8;24(17):R808-10. doi: 10.1016/j.cub.2014.07.026.

Authors

Meghan C Barnhart-Dailey¹, Daniel R Foltz²

Affiliations

¹ Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22901, USA.
² Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22901, USA; Department of Cell Biology, University of Virginia, Charlottesville, VA 22901, USA. Electronic address: drf3q@virginia.edu.

Abstract

The Mis18 complex is a critical player in determining when and where centromeres are built. A new study identifies Polo-like kinase (Plk1) as a positive regulator required for the localization of Mis18 to centromeres. This is a critical step that is essential for proper centromere function and maintaining the integrity of the genome.

Publication types

Comment

MeSH terms

Autoantigens / metabolism*
Cell Cycle Proteins / metabolism*
Centromere / metabolism*
Chromosomal Proteins, Non-Histone / metabolism*
Humans
Protein Serine-Threonine Kinases / metabolism*
Proto-Oncogene Proteins / metabolism*

Substances

Autoantigens
Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
Proto-Oncogene Proteins
Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding