Abstract
In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.
Keywords:
DNA damage; apoptosis; checkpoint; recombination; synapsis.
Copyright © 2014 by the Genetics Society of America.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis* / genetics
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Caenorhabditis elegans / cytology*
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans Proteins / metabolism
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Cell Cycle Checkpoints* / genetics
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Chromosome Pairing / genetics
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Germ Cells / cytology*
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Meiosis* / genetics
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Mutation / genetics
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Regulatory Sequences, Nucleic Acid / genetics
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Transcription, Genetic
Substances
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Caenorhabditis elegans Proteins