Evaluation of reported cases of pertussis: epidemiological study in a large city in Spain

J Med Microbiol. 2014 Dec;63(Pt 12):1688-1695. doi: 10.1099/jmm.0.079756-0. Epub 2014 Sep 26.

Abstract

We retrospectively analysed the incidence rate of reported cases of pertussis in Barcelona during 2009-2012 according to age, sex, type of medical centre and vaccination status. We included 748 confirmed or suspected cases, 613 (82.0 %) of which were confirmed by laboratory testing and the remaining 135 (18.0 %) by epidemiological evidence. The highest reported incidence of pertussis was amongst <1 year olds [96.1 per 100,000 person-years, 95 % confidence interval (CI): 84.3-109.1]. The majority of confirmed and suspected cases were reported in 2011 and 2012, and the total incidence (confirmed or suspected) was 6.3 (95 % CI: 5.6-6.9) and 4.2 (95 % CI: 3.6-4.7) per 100,000 person-years, respectively. Incidence increased significantly (P = 0.001) in 2011-2012 compared with 2009. Most confirmed cases occurred in children <1 year old (87.9 %). Cases were confirmed by real-time (RT)-PCR (87.5 %; 95 % CI: 81.3-87.6) and bacterial culture (13.7 %; 95 % CI: 11.0-17.1). We recommend performing RT-PCR in suspected cases with no epidemiological link to a confirmed case.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bordetella pertussis / genetics
  • Bordetella pertussis / isolation & purification
  • Child
  • Child, Preschool
  • Demography
  • Epidemiologic Studies
  • Female
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Male
  • Real-Time Polymerase Chain Reaction
  • Spain / epidemiology
  • Urban Population
  • Vaccination / statistics & numerical data
  • Whooping Cough / epidemiology*
  • Young Adult