Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain

J Alzheimers Dis. 2015;44(2):379-83. doi: 10.3233/JAD-141755.

Abstract

Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.

Keywords: Alzheimer's disease; Sepp1; cerebrospinal fluid; choroid plexus; selenium; selenoprotein P; selenoproteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Alzheimer Disease / metabolism*
  • Blotting, Western
  • Brain / metabolism*
  • Choroid Plexus / metabolism*
  • Humans
  • Immunohistochemistry
  • Male
  • Selenoprotein P / metabolism*

Substances

  • Selenoprotein P