Vancomycin pharmacokinetic models: informing the clinical management of drug-resistant bacterial infections

Expert Rev Anti Infect Ther. 2014 Nov;12(11):1371-88. doi: 10.1586/14787210.2014.966081.

Abstract

This review aims to critically evaluate the pharmacokinetic literature describing the use of vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Guidelines recommend that trough concentrations be used to guide vancomycin dosing for the treatment of MRSA infections; however, numerous in vitro, animal model and clinical studies have demonstrated that the therapeutic effectiveness of vancomycin is best described by the area under the concentration versus time curve (AUC) divided by the minimum inhibitory concentration (MIC) of the infecting organism (AUC/MIC). Among patients with lower respiratory tract infections, an AUC/MIC ≥400 was associated with a superior clinical and bacteriological response. Similarly, patients with MRSA bacteremia who achieved an Etest AUC/MIC ≥320 within 48 h were 50% less likely to experience treatment failure. For other patient populations and different clinical syndromes (e.g., children, the elderly, patients with osteomyelitis, etc.), pharmacokinetic/pharmacodynamic studies and prospective clinical trials are needed to establish appropriate therapeutic targets.

Keywords: MRSA; Staphylococcus aureus; aminoglycoside; antibiotic; critical care; glycopeptide; infectious disease; pharmacodynamic; pharmacometrics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / microbiology
  • Drug Resistance, Bacterial*
  • Humans
  • Vancomycin / pharmacokinetics*
  • Vancomycin / therapeutic use
  • Vancomycin Resistance*

Substances

  • Anti-Bacterial Agents
  • Vancomycin