Abstract
Self-folded redox/acid dual-responsive nanocarriers (RAD-NCs) are developed for physiologically triggered delivery of anticancer drugs. The evidenced redox/acid responsiveness, facile decoration of ligands, and active tumor-targeting capability of RAD-NCs suggest their potential as a promising formulation for tumor-targeted chemotherapy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents* / administration & dosage
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Antineoplastic Agents* / chemistry
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Cell Survival / drug effects
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Doxorubicin* / administration & dosage
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Doxorubicin* / chemistry
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Drug Carriers* / administration & dosage
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Drug Carriers* / chemistry
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Folic Acid* / administration & dosage
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Folic Acid* / chemistry
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Glutathione / chemistry
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HeLa Cells
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Humans
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Nanoparticles* / administration & dosage
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Nanoparticles* / chemistry
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Oxidation-Reduction
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Peptides / chemistry
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Polyethylene Glycols / chemistry
Substances
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Antineoplastic Agents
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Drug Carriers
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Peptides
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polyserine
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Polyethylene Glycols
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Doxorubicin
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Folic Acid
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Glutathione