Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis

Adv Mater. 2014 Dec 23;26(48):8154-62. doi: 10.1002/adma.201402996. Epub 2014 Oct 20.

Abstract

Photothermal ablation of primary tumors with single-walled carbon nanotubes is demonstrated to be able to trigger significant adaptive immune responses, which are not observed if tumors are removed by surgical resection. Such a treatment in combination with anti-CTLA-4 antibody therapy is able to prevent the development of tumor metastasis, which is a major cause of cancer death.

Keywords: anti-CTLA-4; cancer metastasis inhibition; immunotherapy; photothermal therapy; single-walled carbon nanotubes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / chemistry*
  • Antibodies / immunology
  • Antibodies / therapeutic use
  • CTLA-4 Antigen / immunology*
  • Cytokines / metabolism
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy
  • Mice
  • Mice, Inbred BALB C
  • Nanotubes, Carbon / chemistry*
  • Phototherapy
  • Polyethylene Glycols / chemistry
  • Survival Rate

Substances

  • Antibodies
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Cytokines
  • Nanotubes, Carbon
  • Polyethylene Glycols