Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports

Int J STD AIDS. 2015 Oct;26(11):831-4. doi: 10.1177/0956462414556330. Epub 2014 Oct 20.

Abstract

In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.

Keywords: AIDS; HIV; antiretroviral therapy; darunavir; dolutegravir; resistance; treatment; treatment experienced.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antiretroviral Therapy, Highly Active*
  • CD4 Lymphocyte Count
  • Drug Resistance, Viral / drug effects
  • Female
  • HIV Infections / drug therapy
  • HIV-1 / drug effects
  • Humans
  • Male
  • Treatment Outcome
  • Viral Load