Varenicline is a partial agonist on cerebral nicotine receptors and is indicated for smoking cessation. There are only a few case reports of intended overdose of varenicline. We report a history of a 45-year-old woman who ingested 40-50 mg varenicline. She spontaneously vomited shortly after ingestion which may be due to varenicline's effect on gastrointestinal 5-hydroxytryptamine3-receptors. At admission to hospital she received activated charcoal. ECG-monitoring and blood samples were all normal. She was discharged the following day.