The rabbit blood shunt subarachnoid haemorrhage model

Acta Neurochir Suppl. 2015:120:337-42. doi: 10.1007/978-3-319-04981-6_58.

Abstract

The recently introduced rabbit blood shunt subarachnoid haemorrhage model is based on the two standard procedures of subclavian artery cannulation and transcutaneous cisterna magna puncture. An extracorporeal shunt placed in between the arterial system and the subarachnoid space allows examiner-independent SAH in a closed cranium. Despite its straightforwardness, it is worth examining some specific features and characteristics of the model. We outline technical considerations to successfully perform the model with minimal mortality and morbidity. In addition, we discuss outcome measures, advantages and limitations, and the applicability of the model for the study of early brain injury and delayed cerebral vasospasm after SAH.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cisterna Magna / diagnostic imaging
  • Cisterna Magna / physiopathology*
  • Disease Models, Animal*
  • Rabbits*
  • Radiography
  • Subarachnoid Hemorrhage / complications
  • Subarachnoid Hemorrhage / diagnostic imaging
  • Subarachnoid Hemorrhage / physiopathology*
  • Subarachnoid Space / diagnostic imaging
  • Subarachnoid Space / physiopathology
  • Subclavian Artery / diagnostic imaging
  • Subclavian Artery / physiopathology
  • Vasospasm, Intracranial / diagnostic imaging
  • Vasospasm, Intracranial / etiology
  • Vasospasm, Intracranial / physiopathology*