Extracellular matrix assembly: a multiscale deconstruction

Nat Rev Mol Cell Biol. 2014 Dec;15(12):771-85. doi: 10.1038/nrm3902. Epub 2014 Nov 5.

Abstract

The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Basement Membrane / chemistry
  • Basement Membrane / metabolism
  • Extracellular Matrix / chemistry*
  • Extracellular Matrix / metabolism*
  • Extracellular Matrix Proteins / chemistry
  • Extracellular Matrix Proteins / metabolism
  • Humans
  • Neurons / cytology
  • Proteoglycans / metabolism

Substances

  • Extracellular Matrix Proteins
  • Proteoglycans