A new prenylated indole diketopiperazine alkaloid from Eurotium cristatum

Molecules. 2014 Nov 3;19(11):17839-47. doi: 10.3390/molecules191117839.

Abstract

A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey's method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Cell Line
  • Diketopiperazines / chemistry*
  • Diketopiperazines / isolation & purification*
  • Eurotium / chemistry*
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology
  • Indoles / chemistry*
  • Indoles / isolation & purification*
  • Indoles / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice

Substances

  • Alkaloids
  • Diketopiperazines
  • Free Radical Scavengers
  • Indoles
  • indole