Insulin-like growth factor I receptors on erythrocytes in NIDDM

Diabetes Res Clin Pract. 1989 Feb 15;6(2):95-101. doi: 10.1016/0168-8227(89)90112-5.

Abstract

We examined 125I-insulin-like growth factor I (125I-IGF-I) binding to erythrocytes from 24 normal and 21 non-insulin-dependent diabetic (NIDDM) subjects. 125I-IGF-I binding to human erythrocytes was specifically inhibited by unlabeled IGF-I, and Scatchard analysis indicated a curvilinear plot. There was a significant difference in IGF-I binding between normal and diabetic subjects (7.78 +/- 0.42 vs. 5.80 +/- 0.33%/2.4 x 10(9) cells/ml, P less than 0.001). Among diabetic patients, IGF-I binding to erythrocytes from those with retinopathy and those without retinopathy was comparable. These results suggested that decreased IGF-I binding might be a factor responsible for some pathological features such as delayed wound healing in diabetic patients.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Erythrocytes / metabolism
  • Erythrocytes / ultrastructure*
  • Female
  • Humans
  • Insulin-Like Growth Factor I / analysis
  • Insulin-Like Growth Factor I / metabolism
  • Insulin-Like Growth Factor I / physiology
  • Male
  • Middle Aged
  • Radioimmunoassay
  • Receptors, Cell Surface / blood*
  • Receptors, Somatomedin

Substances

  • Receptors, Cell Surface
  • Receptors, Somatomedin
  • Insulin-Like Growth Factor I