Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children

Pediatr Infect Dis J. 2014 Dec;33(12):1285-7. doi: 10.1097/INF.0000000000000420.

Abstract

The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV wheezy bronchitis. lactate dehydrogenase values were inversely associated with subsequent need for oxygen therapy. lactate dehydrogenase may be a useful biomarker predicting disease severity in RV wheezy bronchitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / analysis*
  • Bronchitis / diagnosis*
  • Bronchitis / pathology
  • Child, Preschool
  • Cytokines / analysis
  • Female
  • Humans
  • Infant
  • L-Lactate Dehydrogenase / analysis*
  • Male
  • Nasal Mucosa / chemistry*
  • Picornaviridae Infections / diagnosis*
  • Picornaviridae Infections / pathology
  • Retrospective Studies
  • Rhinovirus / isolation & purification
  • Severity of Illness Index*
  • Viral Load

Substances

  • Biomarkers
  • Cytokines
  • L-Lactate Dehydrogenase