Abstract
We report the first case in France of a high-level azithromycin-resistant Neisseria gonorrhoeae (minimum inhibitory concentration (MIC) = 96 mg/L) assigned to MLST7363 (NG-MAST ST6360), also resistant to ciprofloxacin and tetracycline but susceptible to ceftriaxone. The patient was a 51 year-old heterosexual man who returned following 1g azithromycin monotherapy. Mechanisms of azithromycin resistance were a C2599T mutation in the four copies of the rrl gene and a novel mutation in the promoter of the mtrR gene.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / therapeutic use*
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Azithromycin / therapeutic use*
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Drug Resistance, Bacterial*
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France
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Gonorrhea / drug therapy*
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Gonorrhea / microbiology
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Neisseria gonorrhoeae / drug effects*
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Neisseria gonorrhoeae / genetics
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Neisseria gonorrhoeae / isolation & purification*
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Sequence Analysis, DNA
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Spectinomycin / therapeutic use
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Azithromycin
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Spectinomycin