Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru

Trop Med Int Health. 2015 Mar;20(3):322-5. doi: 10.1111/tmi.12430. Epub 2014 Dec 23.

Abstract

Objective: To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru.

Methods: We studied new smear-positive TB adults that were started on MDR TB treatment or that were switched to it between June 2008 and December 2011.

Results: Time from the first positive smear to MDR-TB treatment was >30 days in 35% (13/37) of patients. Among the 27% (24/88) of patients that switched to MDR-TB treatment, time from the last dose of a drug-susceptible regimen was >30 days.

Conclusion: Start of and switching to MDR TB treatment is still delayed.

Keywords: Peru; Perú; Pérou; Tiempo hasta el inicio del tratamiento; Tuberculosis; multidrug resistant; multirresistente; multirésistante; temps jusqu'au traitement; time to treatment; tuberculose; tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antitubercular Agents / therapeutic use*
  • Drug Substitution / statistics & numerical data
  • Female
  • Humans
  • Incidence
  • Male
  • Outcome Assessment, Health Care
  • Peru / epidemiology
  • Retrospective Studies
  • Time Factors
  • Tuberculosis, Multidrug-Resistant / drug therapy*
  • Tuberculosis, Multidrug-Resistant / epidemiology
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / epidemiology

Substances

  • Antitubercular Agents