Abstract
Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.
MeSH terms
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Acetylglucosamine / metabolism*
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Animals
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Autophagy / physiology*
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Endosomes / physiology*
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Humans
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Lysosomes / physiology*
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Membrane Fusion*
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N-Acetylglucosaminyltransferases / metabolism*
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Phagosomes / physiology*
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Qb-SNARE Proteins / metabolism*
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Qc-SNARE Proteins / metabolism*
Substances
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Qb-SNARE Proteins
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Qc-SNARE Proteins
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SNAP29 protein, human
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N-Acetylglucosaminyltransferases
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UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
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Acetylglucosamine