Sugar modification inhibits autophagosome-lysosome fusion

Nat Cell Biol. 2014 Dec;16(12):1132-3. doi: 10.1038/ncb3078.

Abstract

Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.

Publication types

  • Comment

MeSH terms

  • Acetylglucosamine / metabolism*
  • Animals
  • Autophagy / physiology*
  • Endosomes / physiology*
  • Humans
  • Lysosomes / physiology*
  • Membrane Fusion*
  • N-Acetylglucosaminyltransferases / metabolism*
  • Phagosomes / physiology*
  • Qb-SNARE Proteins / metabolism*
  • Qc-SNARE Proteins / metabolism*

Substances

  • Qb-SNARE Proteins
  • Qc-SNARE Proteins
  • SNAP29 protein, human
  • N-Acetylglucosaminyltransferases
  • UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
  • Acetylglucosamine