Sleep duration and cardiometabolic risk factors among individuals with type 2 diabetes

Sleep Med. 2015 Jan;16(1):119-25. doi: 10.1016/j.sleep.2014.10.006. Epub 2014 Oct 23.

Abstract

Objective: To examine the association between sleep duration and cardiometabolic risk factors among individuals with recently diagnosed type 2 diabetes (n = 391).

Methods: Sleep duration was derived using a combination of questionnaire and objective heart rate and movement sensing in the UK ADDITION-Plus study (2002-2007). Adjusted means were estimated for individual cardiometabolic risk factors and clustered cardiometabolic risk (CCMR) by five categories of sleep duration.

Results: We observed a J-shaped association between sleep duration and CCMR - individuals sleeping 7 to <8 h had a significantly better CCMR profile than those sleeping ≥9 h. Independent of physical activity and sedentary time, individuals sleeping 7 to <8 h had lower triacylglycerol (0.62 mmol/l (0.29, 1.06)) and higher high-density lipoprotein (HDL)-cholesterol levels (0.23 mmol/l (0.16, 0.30)) compared with those sleeping ≥9 h, and a lower waist circumference (7.87 cm (6.06, 9.68)) and body mass index (BMI) (3.47 kg/m(2) (2.69, 4.25)) than those sleeping <6 h. Although sleeping 7 to <8 h was associated with lower levels of systolic and diastolic blood pressure, HbA1c, total cholesterol, and low-density lipoprotein (LDL)-cholesterol, these associations were not statistically significant.

Conclusions: Sleep duration has a J-shaped association with CCMR in individuals with diabetes, independent of potential confounding. Health promotion interventions might highlight the importance of adequate sleep in this high-risk population.

Keywords: BMI; Cardiovascular risk; Lipids; Sleep duration; Type 2 diabetes; Waist circumference.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actigraphy
  • Adult
  • Aged
  • Behavior Therapy
  • Blood Pressure
  • Body Mass Index
  • Cardiovascular Diseases / etiology
  • Cholesterol / blood
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetes Mellitus, Type 2 / therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Sedentary Behavior
  • Self Report
  • Sleep / physiology*
  • Time Factors
  • Triglycerides / blood
  • Waist Circumference

Substances

  • Triglycerides
  • Cholesterol