Abstract
Invasive fungal infections caused by filamentous fungi are devastating diseases that occur in patients with a variety of immunosuppressive conditions. This review focuses on the pathogenesis of the most important invasive mycosis in the human being caused by the filamentous fungi Aspergillus, Fusarium, Scedosporium and mucorales. The first contact between the mould and the patient, the host defense to different fungi, including the role of mucosa in the innate immune system, the whole innate immune recognition receptors, and the pathways connecting innate and adaptive immunity, as well as the virulence factors of fungi, are discussed in this paper.
Keywords:
Aspergillus; Dectin-1; Dectina-1; Fusarium; Mucorales; Pentraxin-3; Pentraxina-3; Receptores toll-like; Scedosporium; Toll-like receptors.
Copyright © 2014 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptive Immunity
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Antibodies, Fungal / biosynthesis
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Antibodies, Fungal / immunology
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Aspergillosis / etiology
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Aspergillosis / immunology
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Aspergillosis / microbiology
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Fungemia / etiology*
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Fungemia / immunology
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Fungemia / microbiology
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Fungi / genetics
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Fungi / immunology
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Fungi / pathogenicity
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Fusariosis / etiology
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Fusariosis / immunology
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Fusariosis / microbiology
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Genetic Predisposition to Disease
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Host-Pathogen Interactions / immunology
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Humans
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Immunity, Innate
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Immunity, Mucosal / immunology
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Immunocompromised Host*
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Lectins / immunology
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Lymphocyte Subsets / immunology
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Lymphokines / metabolism
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Models, Immunological
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Mucormycosis / etiology
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Mucormycosis / immunology
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Receptors, Pattern Recognition / immunology
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Scedosporium / isolation & purification
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Scedosporium / pathogenicity
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Toll-Like Receptors / immunology
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Virulence / genetics
Substances
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Antibodies, Fungal
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Lectins
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Lymphokines
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Receptors, Pattern Recognition
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Toll-Like Receptors