Resolving lipids: lipoxins regulate reverse cholesterol transport

Abstract

Disruptions in cholesterol homeostasis contribute to cardiovascular disease (CVD). In a recent issue of Cell Metabolism, Demetz et al. (2014) report that endogenous lipoxygenase-mediated metabolism of another lipid, arachidonic acid, produces lipoxins that regulate reverse cholesterol transport. These results suggest that lipoxins may represent a novel class of therapeutics for CVD.